AKOS 022

Catalog No. Size PriceQuantity
M11485-2 2mg solid $150
M11485-10 10mg solid $450


AKOS 022, also known as AKOS-022075291, is a VDAC1 inhibitor. AKOS-22 inhibits both VDAC1 oligomerization and apoptosis in a concentration-dependent manner.

Product information

CAS Number: 878983-38-1

Molecular Weight: 467.87

Formula: C22H21ClF3N3O3




Chemical Name: 1-(4-Chloro-phenyl)-3-[4-(4-trifluoromethoxy-phenylamino)-piperidin-1-yl]-pyrrolidine-2, 5-dione

Smiles: O=C1C(CC(=O)N1C1C=CC(Cl)=CC=1)N1CCC(CC1)NC1C=CC(=CC=1)OC(F)(F)F


InChi: InChI=1S/C22H21ClF3N3O3/c23-14-1-5-17(6-2-14)29-20(30)13-19(21(29)31)28-11-9-16(10-12-28)27-15-3-7-18(8-4-15)32-22(24,25)26/h1-8,16,19,27H,9-13H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 125 mg/mL (267.17 mM)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200


  1. Ben-Hail D, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protectagainst Mitochondrial Dysfunction. Biol Chem. 2016 Nov 25;291(48):24986-25003.

Products are for research use only. Not for human use.

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