Description
Pomalidomide 4'-PEG1-azide is functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a PEG1 linker with terminal azide ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
Product information
CAS Number: 2271036-44-1
Molecular Weight: 386.36
Formula: C17H18N6O5
Synonym:
Pomalidomide-PEG1-C2-N3
Chemical Name: 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2, 6-dioxo-3-piperidinyl)-1H-isoindole-1, 3(2H)-dione
Smiles: [N-]=[N+]=NCCOCCNC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O
InChiKey: NJPMWHWTBBYBDY-UHFFFAOYSA-N
InChi: InChI=1S/C17H18N6O5/c18-22-20-7-9-28-8-6-19-11-3-1-2-10-14(11)17(27)23(16(10)26)12-4-5-13(24)21-15(12)25/h1-3,12,19H,4-9H2,(H,21,24,25)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2.
Products are for research use only. Not for human use.
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