BC1618 is an orally active Fbxo48 inhibitor that stimulates adenosine monophosphate (AMP)-activated protein kinase (Ampk)-dependent signaling. BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity.
CAS Number: 2222094-18-8
Molecular Weight: 415.45
Chemical Name: 1-(dibenzylamino)-3-(4-(trifluoromethyl)phenoxy)propan-2-ol
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 83 mg/mL(199.78 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
BC1618 interrupts Fbxo48/pAmpkα interaction. BC1618 facilitates mitochondrial fission and autophagy.
Consistent with augmenting Ampk activity, BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity in high-fat-diet-induced obese mice.
- Yuan Liu, et al. Nat Chem Biol. 2021 Mar;17(3):298-306.
Products are for research use only. Not for human use.
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