Nutlin-C1-amido-PEG4-C2-N3


Catalog No. Size PriceQuantity
M11519-2 Contact sales@xcessbio.com for quotation $100
M11519-10 Contact sales@xcessbio.com for quotation $100

Description

Nutlin-C1-amido-PEG4-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Nutlin 3 based MDM2 ligand and 4-unit PEG linker used in PROTAC technology.

Product information

CAS Number: 2369022-70-6

Molecular Weight: 883.82

Formula: C42H52Cl2N8O9

Synonym:

MDM2 Ligand-Linker Conjugates 1

E3 ligase Ligand-Linker Conjugates 48

Chemical Name: N-(14-azido-3, 6, 9, 12-tetraoxatetradecan-1-yl)-2-{4-[(4R, 5S)-4, 5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4, 5-dihydro-1H-imidazole-1-carbonyl]-2-oxopiperazin-1-yl}acetamide

Smiles: CC(C)OC1=CC(=CC=C1C1=N[C@@H]([C@H](C2C=CC(Cl)=CC=2)N1C(=O)N1CC(=O)N(CC(=O)NCCOCCOCCOCCOCCN=[N+]=[N-])CC1)C1C=CC(Cl)=CC=1)OC

InChiKey: YLHONJUOEKAZKP-PVXQIPPMSA-N

InChi: InChI=1S/C42H52Cl2N8O9/c1-29(2)61-36-26-34(56-3)12-13-35(36)41-48-39(30-4-8-32(43)9-5-30)40(31-6-10-33(44)11-7-31)52(41)42(55)51-17-16-50(38(54)28-51)27-37(53)46-14-18-57-20-22-59-24-25-60-23-21-58-19-15-47-49-45/h4-13,26,29,39-40H,14-25,27-28H2,1-3H3,(H,46,53)/t39-,40+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Gu S, et al. PROTACs: An Emerging Targeting Technique for Protein Degradation in Drug Discovery. Bioessays. 2018 Apr;40(4):e1700247.

Products are for research use only. Not for human use.

Payment & Security

PayPal Venmo

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed