Catalog No. Size PriceQuantity
M11556-2 2mg solid $85
M11556-10 10mg solid $255


Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs.

Product information

CAS Number: 1061605-21-7

Molecular Weight: 332.26

Formula: C15H12N2O7


Cereblon ligand 3

E3 ligase Ligand 3


Chemical Name: 2-{[2-(2, 6-dioxopiperidin-3-yl)-1, 3-dioxo-2, 3-dihydro-1H-isoindol-4-yl]oxy}acetic acid

Smiles: OC(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O


InChi: InChI=1S/C15H12N2O7/c18-10-5-4-8(13(21)16-10)17-14(22)7-2-1-3-9(12(7)15(17)23)24-6-11(19)20/h1-3,8H,4-6H2,(H,19,20)(H,16,18,21)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 66 mg/mL(198.63 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200


  1. Krajcovicova S, et al. Chem Commun (Camb). 2019 Jan 17;55(7):929-932.

Products are for research use only. Not for human use.

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