SMARCA-BD ligand 1 for Protac dihydrochloride


Catalog No. Size PriceQuantity
M11577-2 2mg solid $145
M11577-10 10mg solid $435

Description

SMARCA-BD ligand 1 for Protac dihydrochloride is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.

Product information

CAS Number: 2369053-68-7

Molecular Weight: 344.24

Formula: C14H19Cl2N5O

Chemical Name: 2-[6-amino-5-(piperazin-1-yl)pyridazin-3-yl]phenol dihydrochloride

Smiles: Cl.Cl.NC1=NN=C(C=C1N1CCNCC1)C1=CC=CC=C1O

InChiKey: INBBYNMFULAIMY-UHFFFAOYSA-N

InChi: InChI=1S/C14H17N5O.2ClH/c15-14-12(19-7-5-16-6-8-19)9-11(17-18-14)10-3-1-2-4-13(10)20;;/h1-4,9,16,20H,5-8H2,(H2,15,18);2*1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680.

Products are for research use only. Not for human use.

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