AP1867-2-(carboxymethoxy)


Catalog No. Size PriceQuantity
M11581-2 2mg solid $215
M11581-10 10mg solid $765

Description

AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules.

Product information

CAS Number: 2230613-03-1

Molecular Weight: 693.78

Formula: C38H47NO11

Synonym:

PROTAC FKBP12-binding moiety 2

Chemical Name: 2-{2-[(1R)-3-(3, 4-dimethoxyphenyl)-1-[(2S)-1-[(2S)-2-(3, 4, 5-trimethoxyphenyl)butanoyl]piperidine-2-carbonyloxy]propyl]phenoxy}acetic acid

Smiles: CC[C@@H](C1=CC(OC)=C(OC)C(=C1)OC)C(=O)N1CCCC[C@H]1C(=O)O[C@H](CCC1C=C(OC)C(=CC=1)OC)C1=CC=CC=C1OCC(O)=O

InChiKey: UYXSZUBFOQLRNQ-BTIIJPOSSA-N

InChi: InChI=1S/C38H47NO11/c1-7-26(25-21-33(46-4)36(48-6)34(22-25)47-5)37(42)39-19-11-10-13-28(39)38(43)50-30(27-12-8-9-14-29(27)49-23-35(40)41)17-15-24-16-18-31(44-2)32(20-24)45-3/h8-9,12,14,16,18,20-22,26,28,30H,7,10-11,13,15,17,19,23H2,1-6H3,(H,40,41)/t26-,28-,30+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

dTAG molecules engage FKBP12F36V and CRBN.

References:

  1. Nabet B, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14(5):431-441.

Products are for research use only. Not for human use.

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