Hydroxy-PEG3-(CH2)2-Boc


Catalog No. Size PriceQuantity
M11634-2 2mg solid $80
M11634-10 10mg solid $240

Description

Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196). Hydroxy-PEG2-(CH2)2-Boc is also a PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 186020-66-6

Molecular Weight: 278.34

Formula: C13H26O6

Chemical Name: tert-butyl 3-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}propanoate

Smiles: CC(C)(C)OC(=O)CCOCCOCCOCCO

InChiKey: KSXVEOLRERRELV-UHFFFAOYSA-N

InChi: InChI=1S/C13H26O6/c1-13(2,3)19-12(15)4-6-16-8-10-18-11-9-17-7-5-14/h14H,4-11H2,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

References:

  1. Qingqi Chen,et al. The use of isocyanate linkers to make hydrolyzable active agent biopolymer conjugates. Patent WO2004008101A2.

Products are for research use only. Not for human use.

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