NH2-C4-NH-Boc


Catalog No. Size PriceQuantity
M11645-2 2mg solid $80
M11645-10 10mg solid $240

Description

NH2-C4-NH-Boc (compound 15) is a PROTAC linker, which refers to the Alkyl/ether composition. NH2-C4-NH-Boc can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Product information

CAS Number: 68076-36-8

Molecular Weight: 188.27

Formula: C9H20N2O2

Chemical Name: tert-butyl N-(4-aminobutyl)carbamate

Smiles: CC(C)(C)OC(=O)NCCCCN

InChiKey: ZFQWJXFJJZUVPI-UHFFFAOYSA-N

InChi: InChI=1S/C9H20N2O2/c1-9(2,3)13-8(12)11-7-5-4-6-10/h4-7,10H2,1-3H3,(H,11,12)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : 100 mg/mL (531.15 mM; Need ultrasonic) DMSO : 100 mg/mL (531.15 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Jiang F, et al.Discovery of novel small molecule induced selective degradation of the bromodomain and extra-terminal (BET) bromodomain protein BRD4 and BRD2 with cellular potencies.Bioorg Med Chem. 2020 Jan 1;28(1):115181.

Products are for research use only. Not for human use.

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