Description
Boc-C5-O-C5-O-C6-Cl (PROTAC Linker 2) is a PROTAC linker utilized to connect the respective tyrosine kinase inhibitor (TKI) to the E3 recruiting ligand.
Product information
CAS Number: 1835705-52-6
Molecular Weight: 393.00
Formula: C21H41ClO4
Synonym:
PROTAC Linker 2
Chemical Name: tert-butyl 6-({5-[(6-chlorohexyl)oxy]pentyl}oxy)hexanoate
Smiles: CC(C)(C)OC(=O)CCCCCOCCCCCOCCCCCCCl
InChiKey: BCFCLXINSZPNKH-UHFFFAOYSA-N
InChi: InChI=1S/C21H41ClO4/c1-21(2,3)26-20(23)14-8-6-11-17-25-19-13-7-12-18-24-16-10-5-4-9-15-22/h4-19H2,1-3H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO.
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10.
- ARYL SULFONOHYDRAZIDES. US 20170121321 A1.
Products are for research use only. Not for human use.
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