Catalog No. Size PriceQuantity
M11670-2 2mg solid $80
M11670-10 10mg solid $240


Tos-PEG4-THP is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523).

Product information

CAS Number: 86259-89-4

Molecular Weight: 432.53

Formula: C20H32O8S

Chemical Name: 2-(2-{2-[2-(oxan-2-yloxy)ethoxy]ethoxy}ethoxy)ethyl 4-methylbenzene-1-sulfonate



InChi: InChI=1S/C20H32O8S/c1-18-5-7-19(8-6-18)29(21,22)28-17-15-25-13-11-23-10-12-24-14-16-27-20-4-2-3-9-26-20/h5-8,20H,2-4,9-17H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.


  1. Andrew P. Crew, et al. Modulators of proteolysis and associated methods of use. WO2019195609A2.

Products are for research use only. Not for human use.

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