Bis-NH2-PEG2

Bis-NH2-PEG2 (PROTAC Linker 19) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Product information

CAS Number: 929-59-9

Molecular Weight: 148.20

Formula: C6H16N2O2

Synonym:

PROTAC Linker 19

Chemical Name: 2-[2-(2-aminoethoxy)ethoxy]ethan-1-amine

Smiles: NCCOCCOCCN

InChiKey: IWBOPFCKHIJFMS-UHFFFAOYSA-N

InChi: InChI=1S/C6H16N2O2/c7-1-3-9-5-6-10-4-2-8/h1-8H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (1686.91 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References:

1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Products are for research use only. Not for human use.