Catalog No. Size PriceQuantity
M11685-2 2mg solid $170
M11685-10 10mg solid $555


5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase, with IC50s of 9, 20 and 25 nM, respectively.

Product information

CAS Number: 331467-03-9

Molecular Weight: 403.17

Formula: C16H10IN3O2

Chemical Name: (Z, 3E)-3-(hydroxyimino)-5'-iodo-1', 2'-dihydro-1H, 3H-[2, 3'-biindolyliden]-2'-one

Smiles: O/N=C1/C(/NC2=CC=CC=C2/1)=C1/C(=O)NC2=CC=C(I)C=C2/1


InChi: InChI=1S/C16H10IN3O2/c17-8-5-6-12-10(7-8)13(16(21)19-12)15-14(20-22)9-3-1-2-4-11(9)18-15/h1-7,18,22H,(H,19,21)/b15-13-,20-14+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 67.5 mg/mL (167.42 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200


  1. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors? J Biol Chem. 2001 Jan 5;276(1):251-60.

Products are for research use only. Not for human use.

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