ZM 449829

Catalog No. Size PriceQuantity
M11729-2 Contact for quotation $100
M11729-10 Contact for quotation $100


ZM 449829 is a potent, selective and ATP competitive inhibitor of JAK3, with a pIC50 of 6.8. ZM 449829 will be useful pharmacological tools for the investigation of the JAK3.

Product information

CAS Number: 4452-06-6

Molecular Weight: 182.22

Formula: C13H10O

Chemical Name: 1-(naphthalen-2-yl)prop-2-en-1-one

Smiles: C=CC(=O)C1=CC2=CC=CC=C2C=C1


InChi: InChI=1S/C13H10O/c1-2-13(14)12-8-7-10-5-3-4-6-11(10)9-12/h2-9H,1H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

ZM 449829 (compound 22) is a very weak inhibitors of EGF-R (pIC50=5.0) , Jak1 (pIC50=4.7), and tyrosine kinases Lck and CDK4 (pIC50 <5.0). ZM449829 (1 μM; 30 minutes) blocks IL-2-induced STAT5 phosphorylation.


  1. Brown GR, et, al. Naphthyl ketones: a new class of Janus kinase 3 inhibitors. Bioorg Med Chem Lett. 2000 Mar 2010(6)575-9.
  2. Orange JS, et, al. IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function. J Clin Invest. 2011 Apr; 121(4): 1535-48.

Products are for research use only. Not for human use.

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