Bilobetin


Catalog No. Size PriceQuantity
M11749-2 2mg solid $250
M11749-10 10mg solid $940

Description

Bilobetin, an active component of Ginkgo biloba, can reduce blood lipids and improve the effects of insulin. Bilobetin ameliorated insulin resistance, increased the hepatic uptake and oxidation of lipids, reduced very-low-density lipoprotein triglyceride secretion and blood triglyceride levels, enhanced the expression and activity of enzymes involved in β-oxidation and attenuated the accumulation of triglycerides and their metabolites in tissues. Bilobetin also increased the phosphorylation, nuclear translocation and activity of PPARα accompanied by elevated cAMP level and PKA activity.

Product information

CAS Number: 521-32-4

Molecular Weight: 552.48

Formula: C31H20O10

Chemical Name: 8-[5-(5, 7-dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl]-5, 7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one

Smiles: COC1=CC=C(C=C1C1=C2OC(=CC(=O)C2=C(O)C=C1O)C1C=CC(O)=CC=1)C1=CC(=O)C2=C(C=C(O)C=C2O)O1

InChiKey: IWEIJEPIYMAGTH-UHFFFAOYSA-N

InChi: InChI=1S/C31H20O10/c1-39-24-7-4-15(26-12-22(37)29-19(34)9-17(33)10-27(29)40-26)8-18(24)28-20(35)11-21(36)30-23(38)13-25(41-31(28)30)14-2-5-16(32)6-3-14/h2-13,32-36H,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 250 mg/mL (452.51 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Kou XH, et al. Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet. Br J Pharmacol. 2012 Apr;165(8):2692-706.

Products are for research use only. Not for human use.

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