JWG-071

JWG-071 is the first reported kinase-selective chemical probe for ERK5. JWG-071 improves ERK5 activity and BRD4 selectivity. JWG-071 will be a much-needed chemical probe for deconvoluting ERK5 and BRD4 pharmacology.

Product information

CAS Number: 2250323-50-1

Molecular Weight: 612.76

Formula: C34H44N8O3

Chemical Name: 2-(butan-2-yl)-5-({2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]phenyl}amino)-9-methyl-2, 4, 6, 9-tetraazatricyclo[9.4.0.0, ]pentadeca-1(15), 3, 5, 7, 11, 13-hexaen-10-one

Smiles: CC(CC)N1C2=NC(NC3=CC=C(C=C3OC)C(=O)N3CCC(CC3)N3CCN(C)CC3)=NC=C2N(C)C(=O)C2=CC=CC=C12

InChiKey: ACWOMSOYIIVIRV-UHFFFAOYSA-N

InChi: InChI=1S/C34H44N8O3/c1-6-23(2)42-28-10-8-7-9-26(28)33(44)39(4)29-22-35-34(37-31(29)42)36-27-12-11-24(21-30(27)45-5)32(43)41-15-13-25(14-16-41)40-19-17-38(3)18-20-40/h7-12,21-23,25H,6,13-20H2,1-5H3,(H,35,36,37)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO.

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

JWG-071 inhibits ERK5 and LRRK2 with IC50 of 88 and 109 nM, respectively.

References:

1. Wang J, et al. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinonesas Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448

Products are for research use only. Not for human use.