Catalog No. Size PriceQuantity
M11820-2 2mg solid $195
M11820-10 10mg solid $665


ALLO-2 is a potent drug-resistant Smoothened (Smo) mutant antagonist that inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.

Product information

CAS Number: 1357350-60-7

Molecular Weight: 371.32

Formula: C18H12F3N5O

Chemical Name: N-{4-[4-(trifluoromethoxy)phenyl]pyrimidin-2-yl}-1H-indazol-5-amine

Smiles: FC(F)(F)OC1C=CC(=CC=1)C1=CC=NC(NC2C=C3C=NNC3=CC=2)=N1


InChi: InChI=1S/C18H12F3N5O/c19-18(20,21)27-14-4-1-11(2-5-14)15-7-8-22-17(25-15)24-13-3-6-16-12(9-13)10-23-26-16/h1-10H,(H,23,26)(H,22,24,25)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 125 mg/mL (336.64 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200


  1. Tao H, et al. Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of smoothened. Chem Biol. 2011 Apr 22;18(4):432-7.

Products are for research use only. Not for human use.

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