Niclosamide olamine


Catalog No. Size PriceQuantity
M12118-2 Contact sales@xcessbio.com for quotation $100
M12118-10 Contact sales@xcessbio.com for quotation $100

Description

Niclosamide olamine (BAY2353 olamine) is an anthelmintic that disrupts mitochondrial metabolism in parasitic worms and animal models. Niclosamide olamine inhibits STAT3 (IC50 = 0.25 μM) and stimulates autophagy by reversibly inhibiting mammalian target of Rapamycin complex 1 (mTORC1) signaling.

Product information

CAS Number: 1420-04-8

Molecular Weight: 388.20

Formula: C15H15Cl2N3O5

Synonym:

BAY2353 olamine

Chemical Name: 2-aminoethan-1-ol; 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide

Smiles: NCCO.[O-][N+](=O)C1=CC(Cl)=C(C=C1)NC(=O)C1=CC(Cl)=CC=C1O

InChiKey: XYCDHXSQODHSLG-UHFFFAOYSA-N

InChi: InChI=1S/C13H8Cl2N2O4.C2H7NO/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15;3-1-2-4/h1-6,18H,(H,16,19);4H,1-3H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Li SL, Yan J, Zhang YQ, Zhen CL, Liu MY, Jin J, Gao JL, Xiao XL, Shen X, Tai Y, Hu N, Zhang XZ, Sun ZJ, Dong DL. Niclosamide ethanolamine inhibits artery constriction. Pharmacol Res. 2017 Jan;115:78-86.
  2. Wei YY, Xuan XC, Zhang XY, Guo TT, Dong DL. Niclosamide ethanolamine induces trachea relaxation and inhibits proliferation and migration of trachea smooth muscle cells. Eur J Pharmacol. 2019 Jun 15;853:229-235.

Products are for research use only. Not for human use.

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