Balsalazide sodium hydrate


Catalog No. Size PriceQuantity
M12119-2 Contact sales@xcessbio.com for quotation $100
M12119-10 Contact sales@xcessbio.com for quotation $100

Description

Balsalazide sodium hydrate could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway.

Product information

CAS Number: 150399-21-6

Molecular Weight: 437.31

Formula: C17H17N3Na2O8

Synonym:

Balsalazide disodium dihydrate

Chemical Name: 5-[(E)-2-(4-{[3-oxo-3-(sodiooxy)propyl]carbamoyl}phenyl)diazen-1-yl]-2-(sodiooxy)benzoic acid dihydrate

Smiles: O.O.OC(=O)C1=CC(=CC=C1O[Na])/N=N/C1C=CC(=CC=1)C(=O)NCCC(=O)O[Na]

InChiKey: XDCNKOBSQURQOZ-MVIJUDHYSA-L

InChi: InChI=1S/C17H15N3O6.2Na.2H2O/c21-14-6-5-12(9-13(14)17(25)26)20-19-11-3-1-10(2-4-11)16(24)18-8-7-15(22)23;;;;/h1-6,9,21H,7-8H2,(H,18,24)(H,22,23)(H,25,26);;;2*1H2/q;2*+1;;/p-2/b20-19+;;;;

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug.

References:

  1. Do EJ, et al. Suppression of colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway by balsalazide and VSL#3. J Gastroenterol Hepatol. 2016 Aug;31(8):1453-61.
  2. Kruis W, et al. Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses. Gut, 2001. 49(6): p. 783-789.

Products are for research use only. Not for human use.

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