Cytochalasin D (Zygosporin A; NSC 209835) is a potent and cell-permeable inhibitor of actin polymerization derived from fungus, inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D (Zygosporin A; NSC 209835) also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells.Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of YAP.
CAS Number: 22144-77-0
Molecular Weight: 507.62
Chemical Name: (3S, 3aR, 4S, 6S, 6aR, 7E, 10S, 12R, 13E, 15R, 15aR)-3-Benzyl-6, 12-dihydroxy-4, 10, 12-trimethyl-5-methylene-1, 11-dioxo-2, 3, 3a, 4, 5, 6, 6a, 9, 10, 11, 12, 15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate
Smiles: C[C@@]1(O)C=C[C@@H](OC(C)=O)[C@]23[C@H]([C@H](CC4C=CC=CC=4)NC2=O)[C@H](C)C(=C)[C@@H](O)[C@@H]3C=CC[C@H](C)C1=O |t:3,33|
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (197.00 mM; Need ultrasonic and warming)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
- Flanagan MD, et al. Cytochalasins block actin filament elongation by binding to high affinity sites associated with F-actin. J Biol Chem. 1980 Feb 10;255(3):835-8.
- Shoji K, et al. Cytochalasin D acts as an inhibitor of the actin-cofilin interaction. Biochem Biophys Res Commun. 2012 Jul 20;424(1):52-7.
- Ken-Ichi Wada, et al. Hippo pathway regulation by cell morphology and stress fibers. 2011 Sep;138(18):3907-14.
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