Cytochalasin D

Catalog No. Size PriceQuantity
M12120-2 2mg solid $1,145
M12120-10 10mg solid $4,580


Cytochalasin D (Zygosporin A; NSC 209835) is a potent and cell-permeable inhibitor of actin polymerization derived from fungus, inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D (Zygosporin A; NSC 209835) also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells[1][2][3].Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment[4]. Cytochalasin D induces phosphorylation and cytoplasmic retention of YAP.

Product information

CAS Number: 22144-77-0

Molecular Weight: 507.62

Formula: C30H37NO6


Zygosporin A

NSC 209835

Chemical Name: (3S, 3aR, 4S, 6S, 6aR, 7E, 10S, 12R, 13E, 15R, 15aR)-3-Benzyl-6, 12-dihydroxy-4, 10, 12-trimethyl-5-methylene-1, 11-dioxo-2, 3, 3a, 4, 5, 6, 6a, 9, 10, 11, 12, 15-dodecahydro-1H-cycloundeca[d]isoindol-15-yl acetate

Smiles: C[C@@]1(O)C=C[C@@H](OC(C)=O)[C@]23[C@H]([C@H](CC4C=CC=CC=4)NC2=O)[C@H](C)C(=C)[C@@H](O)[C@@H]3C=CC[C@H](C)C1=O |t:3,33|


InChi: InChI=1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9-,15-14-/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (197.00 mM; Need ultrasonic and warming)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200


  1. Flanagan MD, et al. Cytochalasins block actin filament elongation by binding to high affinity sites associated with F-actin. J Biol Chem. 1980 Feb 10;255(3):835-8.
  2. Shoji K, et al. Cytochalasin D acts as an inhibitor of the actin-cofilin interaction. Biochem Biophys Res Commun. 2012 Jul 20;424(1):52-7.
  3. Ken-Ichi Wada, et al. Hippo pathway regulation by cell morphology and stress fibers. 2011 Sep;138(18):3907-14.

Products are for research use only. Not for human use.

Payment & Security

American Express Diners Club Discover JCB Mastercard PayPal Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed