(S)-Seco-Duocarmycin SA


Catalog No. Size PriceQuantity
M12138-2 2mg solid $1,490
M12138-10 10mg solid $5,960

Description

(S)-Seco-Duocarmycin SA is a DNA alkylator, cytotoxic to cancer cells, and acts as a ADC cytotoxin for antibody-drug conjugates.

Product information

CAS Number: 152785-82-5

Molecular Weight: 513.93

Formula: C25H24ClN3O7

Chemical Name: methyl (8S)-8-(chloromethyl)-4-hydroxy-6-(5, 6, 7-trimethoxy-1H-indole-2-carbonyl)-3H, 6H, 7H, 8H-pyrrolo[3, 2-e]indole-2-carboxylate

Smiles: COC1=C(OC)C2NC(=CC=2C=C1OC)C(=O)N1C[C@@H](CCl)C2C1=CC(O)=C1NC(=CC=21)C(=O)OC

InChiKey: SDJNZXKVYYJDDM-GFCCVEGCSA-N

InChi: InChI=1S/C25H24ClN3O7/c1-33-18-6-11-5-14(27-20(11)23(35-3)22(18)34-2)24(31)29-10-12(9-26)19-13-7-15(25(32)36-4)28-21(13)17(30)8-16(19)29/h5-8,12,27-28,30H,9-10H2,1-4H3/t12-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Tichenor MS, et al. Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity. J Am Chem Soc. 2007 Sep 5;129(35):10858-69.

Products are for research use only. Not for human use.

Payment & Security

American Express Diners Club Discover JCB Mastercard PayPal Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed