Duocarmycin MB


Catalog No. Size PriceQuantity
M12155-2 2mg solid $665
M12155-10 10mg solid $2,660

Description

Duocarmycin MB is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MB can be used against multi-drug resistant cell lines.

Product information

CAS Number: 1613286-58-0

Molecular Weight: 491.97

Formula: C27H26ClN3O4

Chemical Name: tert-butyl N-{2-[(1S)-1-(chloromethyl)-5-hydroxy-1H, 2H, 3H-benzo[e]indole-3-carbonyl]-1H-indol-6-yl}carbamate

Smiles: CC(C)(C)OC(=O)NC1=CC2NC(=CC=2C=C1)C(=O)N1C[C@@H](CCl)C2C3=CC=CC=C3C(O)=CC1=2

InChiKey: IVUIPHKZPNUXGG-MRXNPFEDSA-N

InChi: InChI=1S/C27H26ClN3O4/c1-27(2,3)35-26(34)29-17-9-8-15-10-21(30-20(15)11-17)25(33)31-14-16(13-28)24-19-7-5-4-6-18(19)23(32)12-22(24)31/h4-12,16,30,32H,13-14H2,1-3H3,(H,29,34)/t16-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Searcey M. Duocarmycins--natures prodrugs? Curr Pharm Des. 2002;8(15):1375-89.

Products are for research use only. Not for human use.

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