Duocarmycin MA


Catalog No. Size PriceQuantity
M12157-2 2mg solid $1,105
M12157-10 10mg solid $4,420

Description

Duocarmycin MA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MA can be used against multi-drug resistant cell lines.

Product information

CAS Number: 1613286-57-9

Molecular Weight: 611.09

Formula: C34H31ClN4O5

Chemical Name: tert-butyl N-[4-({2-[(1S)-1-(chloromethyl)-5-hydroxy-1H, 2H, 3H-benzo[e]indole-3-carbonyl]-1H-indol-6-yl}carbamoyl)phenyl]carbamate

Smiles: CC(C)(C)OC(=O)NC1C=CC(=CC=1)C(=O)NC1=CC2NC(=CC=2C=C1)C(=O)N1C[C@@H](CCl)C2C3=CC=CC=C3C(O)=CC1=2

InChiKey: MZXQBIDDBQCHFP-OAQYLSRUSA-N

InChi: InChI=1S/C34H31ClN4O5/c1-34(2,3)44-33(43)37-22-11-8-19(9-12-22)31(41)36-23-13-10-20-14-27(38-26(20)15-23)32(42)39-18-21(17-35)30-25-7-5-4-6-24(25)29(40)16-28(30)39/h4-16,21,38,40H,17-18H2,1-3H3,(H,36,41)(H,37,43)/t21-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Searcey M. Duocarmycins--natures prodrugs? Curr Pharm Des. 2002;8(15):1375-89.

Products are for research use only. Not for human use.

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