Muscotoxin A

Catalog No. Size PriceQuantity
M12172-2 Contact for quotation $100
M12172-10 Contact for quotation $100


Muscotoxin A is an ADC cytotoxin. Muscotoxin A is a cytotoxic lipopeptide that permeabilizes mammalian cell membranes and induces necrotic cell death.

Product information

CAS Number: 1653999-47-3

Molecular Weight: 1211.41

Formula: C58H90N12O16

Chemical Name: 3-[(6R, 13S, 19R, 22S, 25Z, 28S, 31R, 34S, 37S)-34-benzyl-19, 31-bis[(2S)-butan-2-yl]-25-ethylidene-9-hydroxy-10-(2-hydroxyheptyl)-22, 28-bis(hydroxymethyl)-2, 5, 8, 12, 18, 21, 24, 27, 30, 33, 36-undecaoxo-1, 4, 7, 11, 17, 20, 23, 26, 29, 32, 35-undecaazatricyclo[, ]tetracontan-6-yl]propanamide

Smiles: C/C=C1\NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@H](CC2C=CC=CC=2)NC(=O)[C@@H]2CCCN2C(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)C(O)C(CC(O)CCCCC)NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@H](CO)NC\1=O)[C@@H](C)CC)[C@@H](C)CC


InChi: InChI=1S/C58H90N12O16/c1-7-11-13-20-35(73)28-38-48(76)57(85)62-37(23-24-44(59)74)49(77)60-29-45(75)69-25-16-21-42(69)54(82)64-39(27-34-18-14-12-15-19-34)51(79)67-46(32(5)8-2)56(84)66-40(30-71)52(80)61-36(10-4)50(78)65-41(31-72)53(81)68-47(33(6)9-3)58(86)70-26-17-22-43(70)55(83)63-38/h10,12,14-15,18-19,32-33,35,37-43,46-48,71-73,76H,7-9,11,13,16-17,20-31H2,1-6H3,(H2,59,74)(H,60,77)(H,61,80)(H,62,85)(H,63,83)(H,64,82)(H,65,78)(H,66,84)(H,67,79)(H,68,81)/b36-10-/t32-,33-,35?,37+,38?,39-,40-,41-,42-,43-,46+,47+,48?/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Muscotoxin A (0-13.2 μM ; 24 hours) is cytotoxic to YAC-1, Sp/2, and HeLa cancer cell lines (LC50) ranged from 9.9 to 13.2 μM, causing membrane damage and influx of calcium ions.


  1. Petr Tomek, et al. Cytotoxic Lipopeptide Muscotoxin A, Isolated From Soil Cyanobacterium Desmonostoc Muscorum, Permeabilizes Phospholipid Membranes by Reducing Their Fluidity. Chem Res Toxicol. 2015 Feb 16;28(2):216-24.

Products are for research use only. Not for human use.

Payment & Security

American Express Diners Club Discover JCB Mastercard PayPal Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed