Maytansinoid DM4

Catalog No. Size PriceQuantity
M12182-2 Contact for quotation $100
M12182-10 Contact for quotation $100


Maytansinoid DM4 is a thiol-containing maytansine derivative with highly potent cytotoxicity. Maytansinoid DM4 can be used as a cytotoxic moiety of ADC.

Product information

CAS Number: 799840-96-3

Molecular Weight: 794.39

Formula: C39H56ClN3O10S

Chemical Name: (1S, 3S, 5S, 6S, 20R, 21S)-11-chloro-21-hydroxy-12, 20-dimethoxy-2, 2, 5, 9, 16-pentamethyl-8, 23-dioxo-4, 24-dioxa-9, 22-diazatetracyclo[, .0, ]hexacosa-10(26), 11, 13, 16, 18-pentaen-6-yl (2S)-2-(N, 4-dimethyl-4-sulfanylpentanamido)propanoate

Smiles: C[C@@]12O[C@H]1C(C)(C)[C@@H]1C[C@@](O)(NC(=O)O1)[C@@H](C=CC=C(C)CC1C=C(C(Cl)=C(C=1)OC)N(C)C(=O)C[C@@H]2OC(=O)[C@H](C)N(C)C(=O)CCC(C)(C)S)OC |c:20,t:18|


InChi: InChI=1S/C39H56ClN3O10S/c1-22-13-12-14-27(50-11)39(48)21-29(52-35(47)41-39)37(5,6)34-38(7,53-34)28(51-33(46)23(2)42(8)30(44)15-16-36(3,4)54)20-31(45)43(9)25-18-24(17-22)19-26(49-10)32(25)40/h12-14,18-19,23,27-29,34,48,54H,15-17,20-21H2,1-11H3,(H,41,47)/b14-12-,22-13-/t23-,27+,28-,29-,34-,38-,39-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Maytansine is a natural benzoansamacrolide product isolated from the bark of the African shrub Maytenus ovatus. Maytansine binds to the same site on tubulin as the vinca alkaloids, with similar in vitro inhibition constants, but is a more-potent cytotoxin.


  1. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
  2. Zhao RY, et al. Synthesis and evaluation of hydrophilic linkers for antibody-maytansinoid conjugates. J Med Chem. 2011 May 26;54(10):3606-23.

Products are for research use only. Not for human use.

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