DC1


Catalog No. Size PriceQuantity
M12183-2 Contact sales@xcessbio.com for quotation $100
M12183-10 Contact sales@xcessbio.com for quotation $100

Description

DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is a ADC Cytotoxin. DC1 can be used in synthesis of antibody-drug conjugates for the targeted treatment of cancer.

Product information

CAS Number: 169901-27-3

Molecular Weight: 638.14

Formula: C34H28ClN5O4S

Chemical Name: N-{2-[(1S)-1-(chloromethyl)-5-hydroxy-1H, 2H, 3H-benzo[e]indole-3-carbonyl]-1H-indol-5-yl}-5-(3-sulfanylpropanamido)-1H-indole-2-carboxamide

Smiles: OC1=CC2=C([C@H](CCl)CN2C(=O)C2=CC3=CC(=CC=C3N2)NC(=O)C2=CC3=CC(=CC=C3N2)NC(=O)CCS)C2=CC=CC=C21

InChiKey: ZASLXALGERLDLT-HXUWFJFHSA-N

InChi: InChI=1S/C34H28ClN5O4S/c35-16-20-17-40(29-15-30(41)23-3-1-2-4-24(23)32(20)29)34(44)28-14-19-12-22(6-8-26(19)39-28)37-33(43)27-13-18-11-21(5-7-25(18)38-27)36-31(42)9-10-45/h1-8,11-15,20,38-39,41,45H,9-10,16-17H2,(H,36,42)(H,37,43)/t20-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Kovtun YV, et al. Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen. Cancer Res. 2006 Mar 15;66(6):3214-21.

Products are for research use only. Not for human use.

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