EMI1


Catalog No. Size PriceQuantity
M12188-2 Contact sales@xcessbio.com for quotation $100
M12188-10 Contact sales@xcessbio.com for quotation $100

Description

EMI1 is an EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S inhibitor. EMI1 can be used for the research of mutant EGFR-associated, drug-resistant non-small-cell lung cancer (NSCLC).

Product information

CAS Number: 35773-42-3

Molecular Weight: 334.37

Formula: C20H18N2O3

Chemical Name: 3-(1, 3-benzoxazol-2-yl)-7-(diethylamino)-2H-chromen-2-one

Smiles: CCN(CC)C1=CC2OC(=O)C(=CC=2C=C1)C1=NC2=CC=CC=C2O1

InChiKey: UJOQSHCJYVRZKJ-UHFFFAOYSA-N

InChi: InChI=1S/C20H18N2O3/c1-3-22(4-2)14-10-9-13-11-15(20(23)25-18(13)12-14)19-21-16-7-5-6-8-17(16)24-19/h5-12H,3-4H2,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

EMI1 inhibits PC9 EGFR ex19del/T790M/C797S organoid growth with the EC50 of 131 nM. EMI1 (1 nM-10 μM) potently reduces the interaction of EGFR triple mutant with Shc1. EMI1 (1 nM-100μM) strongly inhibits the viability and increase the caspase 3/7 activity of PC9 EGFR ex19del/T790M/C797S triple-mutant cells than noncancerous human bronchial epithelial (HBE) cells.

References:

  1. Punit Saraon, et al. A drug discovery platform to identify compounds that inhibit EGFR triple mutants. Nat Chem Biol. 2020 May;16(5):577-586.

Products are for research use only. Not for human use.

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