Gefitinib D8


Catalog No. Size PriceQuantity
M12212-2 2mg solid $545
M12212-10 10mg solid $2,180

Description

Gefitinib D8 (ZD1839 D8) is a deuterium labeled Gefitinib. Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells.

Product information

CAS Number: 857091-32-8

Molecular Weight: 454.95

Formula: C22H24ClFN4O3

Synonym:

ZD1839 D8

Chemical Name: N-(3-chloro-4-fluorophenyl)-7-methoxy-6-{3-[(2, 2, 3, 3, 5, 5, 6, 6-H)morpholin-4-yl]propoxy}quinazolin-4-amine

Smiles: [2H]C1([2H])N(CCCOC2=CC3=C(NC4=CC(Cl)=C(F)C=C4)N=CN=C3C=C2OC)C([2H])([2H])C([2H])([2H])OC1([2H])[2H]

InChiKey: XGALLCVXEZPNRQ-IHGLQNJRSA-N

InChi: InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)/i6D2,7D2,9D2,10D2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Pedersen MW, et al. Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII. Br J Cancer. 2005 Oct 17;93(8):915-23.
  2. Moasser MM, et al. The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. Cancer Res. 2001 Oct 1;61(19):7184-8.

Products are for research use only. Not for human use.

Payment & Security

American Express Diners Club Discover JCB Mastercard PayPal Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed