Catalog No. Size PriceQuantity
M12221-2 Contact sales@xcessbio.com for quotation $100
M12221-10 Contact sales@xcessbio.com for quotation $100


Tephrosin is a natural rotenoid which has potent antitumor activities. Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors.

Product information

CAS Number: 76-80-2

Molecular Weight: 410.42

Formula: C23H22O7


Deguelinol I


Chemical Name: (1R, 14R)-14-hydroxy-17, 18-dimethoxy-7, 7-dimethyl-2, 8, 21-trioxapentacyclo[, .0, .0, ]docosa-3, 5, 9, 11, 15, 17, 19-heptaen-13-one

Smiles: CC1(C)C=CC2=C3O[C@@H]4COC5=CC(OC)=C(C=C5[C@]4(O)C(=O)C3=CC=C2O1)OC


InChi: InChI=1S/C23H22O7/c1-22(2)8-7-12-15(30-22)6-5-13-20(12)29-19-11-28-16-10-18(27-4)17(26-3)9-14(16)23(19,25)21(13)24/h5-10,19,25H,11H2,1-4H3/t19-,23-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Treatment of HT-29 cells with tephrosin (0-10μM) inhibits both the ligand-induced and constitutive phosphorylation of EGFR, ErbB2 and ErbB3, and concomitantly suppresses the activation of the downstream signaling molecules such as Akt and Erk1/2 mitogen-activated protein kinase (MAPK).


  1. Choi S, et al. Tephrosin induces internalization and degradation of EGFR and ErbB2 in HT-29 human colon cancer cells. Cancer Lett. 2010 Jul 1;293(1):23-30.

Products are for research use only. Not for human use.

Payment & Security

American Express Diners Club Discover JCB Mastercard PayPal Venmo Visa

Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.

Estimate shipping

You may also like

Recently viewed