76-80-2

Tephrosin is a natural rotenoid which has potent antitumor activities. Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors.

Product information

CAS Number: 76-80-2

Molecular Weight: 410.42

Formula: C23H22O7

Synonym:

Deguelinol I

Hydroxydeguelin

Chemical Name: (1R, 14R)-14-hydroxy-17, 18-dimethoxy-7, 7-dimethyl-2, 8, 21-trioxapentacyclo[12.8.0.0, .0, .0, ]docosa-3, 5, 9, 11, 15, 17, 19-heptaen-13-one

Smiles: CC1(C)C=CC2=C3O[C@@H]4COC5=CC(OC)=C(C=C5[C@]4(O)C(=O)C3=CC=C2O1)OC

InChiKey: AQBZCCQCDWNNJQ-AUSIDOKSSA-N

InChi: InChI=1S/C23H22O7/c1-22(2)8-7-12-15(30-22)6-5-13-20(12)29-19-11-28-16-10-18(27-4)17(26-3)9-14(16)23(19,25)21(13)24/h5-10,19,25H,11H2,1-4H3/t19-,23-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Treatment of HT-29 cells with tephrosin (0-10μM) inhibits both the ligand-induced and constitutive phosphorylation of EGFR, ErbB2 and ErbB3, and concomitantly suppresses the activation of the downstream signaling molecules such as Akt and Erk1/2 mitogen-activated protein kinase (MAPK).

References:

1. Choi S, et al. Tephrosin induces internalization and degradation of EGFR and ErbB2 in HT-29 human colon cancer cells. Cancer Lett. 2010 Jul 1;293(1):23-30.

Products are for research use only. Not for human use.