Khellin

Khellin is a furochromone that can be isolated from Ammi visnuga L.. Khellin is an EGFR inhibitor with an IC50 of 0.15 µM. Khelline has anti-proliferative activity in vitro. Khellin has antispasmodic and coronary vasodilator effects.

Product information

CAS Number: 82-02-0

Molecular Weight: 260.24

Formula: C14H12O5

Chemical Name: 4, 9-dimethoxy-7-methyl-5H-furo[3, 2-g]chromen-5-one

Smiles: CC1=CC(=O)C2=C(O1)C(OC)=C1OC=CC1=C2OC

InChiKey: HSMPDPBYAYSOBC-UHFFFAOYSA-N

InChi: InChI=1S/C14H12O5/c1-7-6-9(15)10-11(16-2)8-4-5-18-12(8)14(17-3)13(10)19-7/h4-6H,1-3H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO: 26 mg/mL(99.9 mM).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Khelline exhibits anti-proliferative activity for MCF-7 cells and Hela cells. Khellin inhibits the pathways of Ca2+ influx which are activated by both noradrenaline and high K+.

References:

1. Omar S, Eriksson LA. Computational study of khellin excited states and photobinding to DNA. Photochem Photobiol Sci. 2009 Aug;8(8):1179-86. doi: 10.1039/b905147c. Epub 2009 Jul 6. PubMed PMID: 19639121.
2. Vanachayangkul P, Byer K, Khan S, Butterweck V. An aqueous extract of Ammi visnaga fruits and its constituents khellin and visnagin prevent cell damage caused by oxalate in renal epithelial cells. Phytomedicine. 2010 Jul;17(8-9):653-8. doi: 10.1016/j.phymed.2009.10.011. Epub 2009 Dec 29. PubMed PMID: 20036111; PubMed Central PMCID: PMC3618668.
3. Fersi H, Platz MS. Nanosecond time-resolved infrared studies of visnagin and khellin triplets and radical ions. J Phys Chem A. 2005 Oct 20;109(41):9206-12. PubMed PMID: 16833259.

Products are for research use only. Not for human use.