Description
(E)-AG 99 ((E)-Tyrphostin 46) is a potent EGFR inhibitor.
Product information
CAS Number: 122520-85-8
Molecular Weight: 204.18
Formula: C10H8N2O3
Synonym:
(E)-Tyrphostin 46
(E)-Tyrphostin AG 99
Chemical Name: (E)-2-cyano-3-(3, 4-dihydroxyphenyl)acrylamide
Smiles: NC(=O)/C(=C/C1=CC(O)=C(O)C=C1)/C#N
InChiKey: USOXQZNJFMKTKJ-XVNBXDOJSA-N
InChi: InChI=1S/C10H8N2O3/c11-5-7(10(12)15)3-6-1-2-8(13)9(14)4-6/h1-4,13-14H,(H2,12,15)/b7-3+
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO: 41 mg/mL(200.8 mM).
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
(E)-AG 99 effectively blocks tyrosine phosphorylation of p145met and promotes cell death accompanied by activation of caspase-like proteases.
References:
- Yamamoto N, et al. Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells. J Cell Sci. 2006 Nov 15;119(Pt 22):4623-33.
Products are for research use only. Not for human use.
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