Isoliquiritin apioside


Catalog No. Size PriceQuantity
M12274-2 2mg solid $225
M12274-10 10mg solid $825

Description

Isoliquiritin apioside, a component isolated from Glycyrrhizae radix rhizome, significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. Isoliquiritin apioside auppresseses invasiveness and angiogenesis of cancer cells and endothelial cells.

Product information

CAS Number: 120926-46-7

Molecular Weight: 550.51

Formula: C26H30O13

Chemical Name: (2E)-3-(4-{[(2S, 3R, 4S, 5S, 6R)-3-{[(2S, 3R, 4R)-3, 4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy}-4, 5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)-1-(2, 4-dihydroxyphenyl)prop-2-en-1-one

Smiles: OC1=CC(O)=C(C=C1)C(=O)/C=C/C1C=CC(=CC=1)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[C@@H]1OC[C@](O)(CO)[C@H]1O

InChiKey: VMMVZVPAYFZNBM-KVFWHIKKSA-N

InChi: InChI=1S/C26H30O13/c27-10-19-20(32)21(33)22(39-25-23(34)26(35,11-28)12-36-25)24(38-19)37-15-5-1-13(2-6-15)3-8-17(30)16-7-4-14(29)9-18(16)31/h1-9,19-25,27-29,31-35H,10-12H2/b8-3+/t19-,20-,21+,22-,23+,24-,25+,26-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Isoliquiritin apioside efficiently suppresses the PMA-induced gelatinolytic MMP-9 activity in HT1080 cells. Isoliquiritin apiosidealso decreases the PMA-induced increase in MMP-9 production in HT1080 cells.Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and endothelial cells (ECs), with no cytotoxicity.

References:

  1. Kim A1, et al. Isoliquiritin Apioside Suppresses in vitro Invasiveness and Angiogenesis of Cancer Cells and Endothelial Cells.Front Pharmacol. 2018 Dec 10;9:1455.

Products are for research use only. Not for human use.

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