Bisabolangelone


Catalog No. Size PriceQuantity
M12285-2 2mg solid $160
M12285-10 10mg solid $505

Description

Bisabolangelone, a sesquiterpene derivative, is isolated from the roots of Osterici Radix. Bisabolangelone possesses anti-inflammatory properties, which inhibits LPS-stimulated inflammation through the blocking of NF-kappaB and MAPK pathways in macrophages. Bisabolangelone has anti-ulcer activities.

Product information

CAS Number: 30557-81-4

Molecular Weight: 248.32

Formula: C15H20O3

Chemical Name: (2Z, 3R, 3aR, 7aS)-3-hydroxy-3, 6-dimethyl-2-(3-methylbut-2-en-1-ylidene)-2, 3, 3a, 4, 7, 7a-hexahydro-1-benzofuran-4-one

Smiles: CC(C)=C/C=C1\O[C@H]2CC(C)=CC(=O)[C@H]2[C@@]\1(C)O

InChiKey: GNWNPLBSEQDDQV-VRBKASCLSA-N

InChi: InChI=1S/C15H20O3/c1-9(2)5-6-13-15(4,17)14-11(16)7-10(3)8-12(14)18-13/h5-7,12,14,17H,8H2,1-4H3/b13-6-/t12-,14+,15-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (402.71 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Jung HW, et al. Bisabolangelone isolated from Ostericum koreanum inhibits the production of inflammatory mediators by down-regulation of NF-kappaB and ERK MAP kinase activity in LPS-stimulated RAW264.7 cells. Int Immunopharmacol. 2010 Feb;10(2):155-62.
  2. Wang J, et al. The anti-ulcer activities of bisabolangelone from Angelica polymorpha. J Ethnopharmacol. 2009 Jun 22;123(2):343-6.

Products are for research use only. Not for human use.

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