Description
FR 167653 free base, an orally active and selective p38 MAPK inhibitor, is a potent suppressor of TNF-α and IL-1β production via specific inhibition of p38 MAPK activity. FR 167653 free base is effective in treating inflammation, relieving trauma and ischemia-reperfusion injury in vivo.
Product information
CAS Number: 158876-65-4
Molecular Weight: 427.43
Formula: C24H18FN5O2
Chemical Name: 1-[7-(4-fluorophenyl)-8-(pyridin-4-yl)-1H, 2H, 3H, 4H-pyrazolo[3, 2-c][1, 2, 4]triazin-2-yl]-2-phenylethane-1, 2-dione
Smiles: O=C(C(=O)C1C=CC=CC=1)N1CCN2N=C(C(=C2N1)C1C=CN=CC=1)C1C=CC(F)=CC=1
InChiKey: LDBDQDCZGRCZED-UHFFFAOYSA-N
InChi: InChI=1S/C24H18FN5O2/c25-19-8-6-17(7-9-19)21-20(16-10-12-26-13-11-16)23-28-30(15-14-29(23)27-21)24(32)22(31)18-4-2-1-3-5-18/h1-13,28H,14-15H2
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vivo:
FR 167653 free base (32 mg/kg; i.h.; 24-48 hours) significantly decreases the extent of acute tubular necrosis.
References:
- Furuichi K, et al. Administration of FR167653, a new anti-inflammatory compound, prevents renal ischaemia/reperfusion injury in mice. Nephrol Dial Transplant. 2002 Mar;17(3):399-407.
- Iwata Y, et al. p38 Mitogen-activated protein kinase contributes to autoimmune renal injury in MRL-Fas lpr mice. J Am Soc Nephrol. 2003 Jan;14(1):57-67.
- Kawashima Y, et al. FR167653 attenuates ischemia and reperfusion injury of the rat lung with suppressing p38mitogen-activated protein kinase. J Heart Lung Transplant. 2001 May;20(5):568-74.
Products are for research use only. Not for human use.
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