Actein

Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in human bladder cancer. Actein has little toxicity in vivo.

Product information

CAS Number: 18642-44-9

Molecular Weight: 676.83

Formula: C37H56O11

Chemical Name: (1R, 1'R, 2R, 3'R, 4S, 4'R, 5S, 5'R, 6'R, 10'S, 12'S, 13'S, 16'R, 18'S, 21'R)-4-hydroxy-4', 5, 6', 12', 17', 17'-hexamethyl-18'-{[(2S, 3R, 4S, 5R)-3, 4, 5-trihydroxyoxan-2-yl]oxy}-3, 6, 9'-trioxaspiro[bicyclo[3.1.0]hexane-2, 8'-hexacyclo[11.9.0.0, .0, .0, .0, ]docosan]-3'-yl acetate

Smiles: CC1(C)[C@@H]2CC[C@@H]3[C@]4(C[C@@H](OC(C)=O)[C@]5(C)[C@@H]6[C@H](C[C@]53C)O[C@]3(C[C@H]6C)O[C@H](O)[C@@]5(C)O[C@H]53)C[C@@]42CC[C@@H]1O[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O

InChiKey: NEWMWGLPJQHSSQ-PSDKAYTQSA-N

InChi: InChI=1S/C37H56O11/c1-17-12-37(29-34(7,47-29)30(42)48-37)46-20-13-32(5)22-9-8-21-31(3,4)23(45-28-27(41)26(40)19(39)15-43-28)10-11-35(21)16-36(22,35)14-24(44-18(2)38)33(32,6)25(17)20/h17,19-30,39-42H,8-16H2,1-7H3/t17-,19-,20+,21+,22+,23+,24-,25+,26+,27-,28+,29-,30+,32+,33-,34+,35-,36+,37-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Yang ZC, et al. Actein enhances TRAIL effects on suppressing gastric cancer progression by activating p53/Caspase-3 signaling. Biochem Biophys Res Commun. 2018 Mar 18;497(4):1177-1183.
2. Ji L, et al. Actein induces autophagy and apoptosis in human bladder cancer by potentiating ROS/JNK and inhibiting AKT pathways. Oncotarget. 2017 Nov 1;8(68):112498-112515.

Products are for research use only. Not for human use.