Description
Sorafenib D4 (Bay 43-9006 D4) is the deuterium labeled Sorafenib. Sorafenib is a multikinase inhibitor IC50s of 6 nM, 20 nM, and 22 nM for Raf-1, B-Raf, and VEGFR-3, respectively.
Product information
CAS Number: 1207560-07-3
Molecular Weight: 468.85
Formula: C21H16ClF3N4O3
Synonym:
Bay 43-9006 (D4)
Chemical Name: 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)(2, 3, 5, 6-H)phenoxy]-N-methylpyridine-2-carboxamide
Smiles: [2H]C1=C(OC2=CC(=NC=C2)C(=O)NC)C([2H])=C([2H])C(NC(=O)NC2=CC(=C(Cl)C=C2)C(F)(F)F)=C1[2H]
InChiKey: MLDQJTXFUGDVEO-KDWOUJHVSA-N
InChi: InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31)/i2D,3D,5D,6D
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
References:
- Wilhelm SM, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004 Oct 1;64(19):7099-109.
Products are for research use only. Not for human use.
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