Hypericin


Catalog No. Size PriceQuantity
M12370-2 2mg solid $150
M12370-10 10mg solid $460

Description

Hypericin is a photosensitive antiviral with anticancer and antidepressant agent derived from Hypericum perforatum. It can inhibit tyrosine kinases with IC50 of 7.5 μM. IC50: 7.5 uM In vitro:The photosensitive of hypericin can induce both apoptosis and necrosis in a concentration and light dose-dependent fashion. PDT with hypericin results in the activation of multiple pathways that can either promote or counteract the cell death program. It can effect cytotoxic to tumor cells by visible light.

Product information

CAS Number: 548-04-9

Molecular Weight: 504.44

Formula: C30H16O8

Chemical Name: 5, 7, 11, 18, 22, 24-hexahydroxy-13, 16-dimethyloctacyclo[13.11.1.1, .0, .0, .0, .0, .0, ]octacosa-1, 3, 5, 7, 10, 12, 14(28), 15, 17, 19(27), 21, 23, 25-tridecaene-9, 20-dione

Smiles: CC1C=C(O)C2=C3C=1C1C4=C(C(=O)C5C6=C(C7=C(C(C2=O)=C(O)C=C7O)C3=C64)C(O)=CC=5O)C(O)=CC=1C

InChiKey: BTXNYTINYBABQR-UHFFFAOYSA-N

InChi: InChI=1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,31-36H,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 25 mg/mL (49.56 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Agostinis P et al. Hypericin in cancer treatment: more light on the way. Int J Biochem Cell Biol. 2002 Mar;34(3):221-41.
  2. Lenard J et al. Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses usinghypericin and rose bengal: inhibition of fusion and syncytia formation. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):158-62.
  3. Hwang MS et al. Inhibition of c-erbB-2 expression an activity in human ovarian carcinoma cells by hypericin. Anticancer Res. 2001 Jul-Aug;21(4A):2649-55.

Products are for research use only. Not for human use.

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