Phenoxodiol


Catalog No. Size PriceQuantity
M12430-2 2mg solid $225
M12430-10 10mg solid $825

Description

Phenoxodiol, a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner.

Product information

CAS Number: 81267-65-4

Molecular Weight: 240.25

Formula: C15H12O3

Synonym:

Idronoxil

Dehydroequol

Haginin E

Chemical Name: 3-(4-hydroxyphenyl)-2H-chromen-7-ol

Smiles: OC1C=CC(=CC=1)C1COC2=CC(O)=CC=C2C=1

InChiKey: ZZUBHVMHNVYXRR-UHFFFAOYSA-N

InChi: InChI=1S/C15H12O3/c16-13-4-1-10(2-5-13)12-7-11-3-6-14(17)8-15(11)18-9-12/h1-8,16-17H,9H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : ≥ 100 mg/mL (416.23 mM) H2O : 1 mg/mL (4.16 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Kamsteeg M, et al. Phenoxodiol--an isoflavone analog--induces apoptosis in chemoresistant ovarian cancer cells. Oncogene. 2003 May 1;22(17):2611-20.
  2. Mahoney S, et al. The effects of phenoxodiol on the cell cycle of prostate cancer cell lines. Cancer Cell Int. 2014 Nov 8;14(1):110.

Products are for research use only. Not for human use.

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