Description
L-Cystathionine is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine plays an important role in cardiovascular protection.
Product information
CAS Number: 56-88-2
Molecular Weight: 222.26
Formula: C7H14N2O4S
Chemical Name: (2S)-2-amino-4-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}butanoic acid
Smiles: N[C@@H](CSCC[C@H](N)C(O)=O)C(O)=O
InChiKey: ILRYLPWNYFXEMH-WHFBIAKZSA-N
InChi: InChI=1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: H2O : 25 mg/mL (112.48 mM; ultrasonic and warming and adjust pH to 11 with NaOH and heat to 80°C) DMSO : 1 mg/mL (4.50 mM; Need ultrasonic)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
Homocysteine obviously induces the apoptosis of HUVECs, and this effect is significantly attenuated by the pretreatment with L-cystathionine. Furthermore, L-cystathionine decreases the production of mitochondrial superoxide anion and the expression of Bax and restrained its translocation to mitochondria, increases mitochondrial membrane potential, inhibits mitochondrial permeability transition pore (MPTP) opening, suppresses the leakage of cytochrome c from mitochondria into the cytoplasm, and downregulated activities of caspase-9 and caspase-3. L-Cystathionine is an important metabolic intermediate in the L-cysteine transsulfuration pathway from L-methionine via L-homocysteine in mammalian tissues.
References:
- Xiuli Wang, et al. L-Cystathionine Protects against Homocysteine-Induced Mitochondria-Dependent Apoptosis of Vascular Endothelial Cells. Oxid Med Cell Longev. 2019 Nov 25;2019:1253289.
- Amino Y, et al. Synthesis and evaluation of L-cystathionine as a standard for amino acid analysis. Biosci Biotechnol Biochem. 2017 Jan;81(1):95-101.
Products are for research use only. Not for human use.
Payment & Security
Your payment information is processed securely. We do not store credit card details nor have access to your credit card information.