Ubiquitin Isopeptidase Inhibitor I, G5

Catalog No. Size PriceQuantity
M12451-2 2mg solid $115
M12451-10 10mg solid $345


Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.

Product information

CAS Number: 108477-18-5

Molecular Weight: 414.39

Formula: C19H14N2O7S



Chemical Name: (3Z, 5Z)-3, 5-bis[(4-nitrophenyl)methylidene]-1-thiane-1, 1, 4-trione

Smiles: [O-][N+](=O)C1C=CC(/C=C2\CS(=O)(=O)C/C(=C\C3C=CC(=CC=3)[N+]([O-])=O)/C\2=O)=CC=1


InChi: InChI=1S/C19H14N2O7S/c22-19-15(9-13-1-5-17(6-2-13)20(23)24)11-29(27,28)12-16(19)10-14-3-7-18(8-4-14)21(25)26/h1-10H,11-12H2/b15-9+,16-10+

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 50 mg/mL (120.66 mM; Need ultrasonic) THF : 3.44 mg/mL (8.30 mM; Need ultrasonic) Acetone : 2.86 mg/mL (6.90 mM; Need ultrasonic) Ethanol : < 1 mg/mL (ultrasonic) (insoluble)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

G5 is capable of activating an apoptosome-independent apoptotic pathway. It targets the ubiquitinproteasome system by inhibiting the ubiquitin isopeptidases. G5 induces a rather unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with upregulation of the BH3-only protein Noxa, stabilization of the inhibitor of apoptosis antagonist Smac, but also the involvement of the death receptor pathway. G5 is a potent apoptotic inducer showing IC50s of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.


  1. Aleo E, et al. Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Res. 2006 Sep 15;66(18):9235-44.

Products are for research use only. Not for human use.

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