Description
STAT5-IN-2 is a STAT5 inhibitor, extracted from reference 1, example 17f. STAT5-IN-2 has potent antileukemic effect.
Product information
CAS Number: 2111834-61-6
Molecular Weight: 397.51
Formula: C26H27N3O
Chemical Name: 1-[2-(1H-indol-5-yloxy)ethyl]-4, 4-dimethyl-6-(pyridin-3-yl)-1, 2, 3, 4-tetrahydroquinoline
Smiles: CC1(C)CCN(CCOC2C=C3C=CNC3=CC=2)C2=CC=C(C=C12)C1=CN=CC=C1
InChiKey: BELIZDRKUICBJC-UHFFFAOYSA-N
InChi: InChI=1S/C26H27N3O/c1-26(2)10-13-29(14-15-30-22-6-7-24-20(16-22)9-12-28-24)25-8-5-19(17-23(25)26)21-4-3-11-27-18-21/h3-9,11-12,16-18,28H,10,13-15H2,1-2H3
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: DMSO : 100 mg/mL (251.57 mM; Need ultrasonic)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥12 months if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
STAT5-IN-2 has EC50 values of 9 μM and 5 μM in K562 and KU812 cells, respectively. STAT5-IN-2 (100 nM-50 µM; 48 hours) has EC50 values of 2.6 µM and 3.5 µM in KG1a and MV-4-11 cells, respectively. STAT5-IN-2 (10 µM; 48 hours) induces apoptosis in all cell lines (K562, KU812, KG1a and MV-4-11 cells). STAT5-IN-2 (10 µM; 24 hours) blocks phosphorylation of STAT5.
References:
- Ludovic Juen, et al. New Inhibitor Targeting Signal Transducer and Activator of Transcription 5 (STAT5) Signaling in Myeloid Leukemias. J Med Chem. 2017 Jul 27;60(14):6119-6136.
Products are for research use only. Not for human use.
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