Ethylene dimethanesulfonate

Catalog No. Size PriceQuantity
M12603-2 2mg solid $80
M12603-10 10mg solid $240


Ethylene dimethane sulfonate is a mild alkylating, non-volatile methanesulfonic diester of ethylene glycol. Ethylene dimethanesulfonate has selective pro-apoptotic effects on LCs.

Product information

CAS Number: 4672-49-5

Molecular Weight: 218.25

Formula: C4H10O6S2

Chemical Name: 2-(methanesulfonyloxy)ethyl methanesulfonate

Smiles: CS(=O)(=O)OCCOS(C)(=O)=O


InChi: InChI=1S/C4H10O6S2/c1-11(5,6)9-3-4-10-12(2,7)8/h3-4H2,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (458.19 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

Ethylene dimethanesulfonate (subcutaneous injection; 75 mg/kg; 7 days) disrupts epididymal function and leads to sperm granuloma formation in rat.


  1. Dutta D, et al. Ethylene dimethane sulfonate (EDS) ablation of Leydig cells in adult rat depletes testosterone resulting in epididymal sperm granuloma: Testosterone replacement prevents granuloma formation. Reprod Biol. 2019 Mar;19(1):89-99.

Products are for research use only. Not for human use.

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