Catalog No. Size PriceQuantity
M12633-2 2mg solid $780
M12633-10 10mg solid $3,120


MSN-125 is a potent Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilization (MOMP) with an IC50 of 4 μM. MSN-125 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity.

Product information

CAS Number: 1592908-16-1

Molecular Weight: 688.61

Formula: C36H38BrN3O6

Chemical Name: (2S)-N-[(2R, 3S)-2-(aminomethyl)-6-[(2-methoxyethoxy)methoxy]-2, 3-dihydro-1-benzofuran-3-yl]-N-[(4-bromophenyl)methyl]-3-phenyl-2-(phenylformamido)propanamide

Smiles: COCCOCOC1=CC2O[C@H](CN)[C@H](C=2C=C1)N(CC1C=CC(Br)=CC=1)C(=O)[C@H](CC1C=CC=CC=1)NC(=O)C1C=CC=CC=1


InChi: InChI=1S/C36H38BrN3O6/c1-43-18-19-44-24-45-29-16-17-30-32(21-29)46-33(22-38)34(30)40(23-26-12-14-28(37)15-13-26)36(42)31(20-25-8-4-2-5-9-25)39-35(41)27-10-6-3-7-11-27/h2-17,21,31,33-34H,18-20,22-24,38H2,1H3,(H,39,41)/t31-,33+,34-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

MSN-125 inhibits tBid/Bax-mediated MOMP in a concentration-dependent manner.


  1. Niu X, et al. A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. Cell Chem Biol. 2017 Apr 20;24(4):493-506.e5.

Products are for research use only. Not for human use.

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