Description
(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2, 3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes.
Product information
CAS Number: 26988-72-7
Molecular Weight: 218.25
Formula: C12H14N2O2
Synonym:
1-Methyl-DL-tryptophan
(Rac)-NLG-8189
Chemical Name: 2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid
Smiles: CN1C=C(CC(N)C(O)=O)C2=CC=CC=C12
InChiKey: ZADWXFSZEAPBJS-UHFFFAOYSA-N
InChi: InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)
Technical Data
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
In Vitro:
(Rac)-Indoximod (1-Methyl-DL-tryptophan; 0.5 mM; 3 days) inhibits tryptophan depletion, thereby partially reversing the growth-inhibitory activity of IFN-γ, but eventually induces cell death regardless of tryptophan depletion.
References:
- Jun-Won Lee,et al. Co-treatment with interferon-γ and 1-methyl tryptophan ameliorates cardiac fibrosis through cardiac myofibroblasts apoptosis. Mol Cell Biochem. 2019 Aug;458(1-2):197-205.
Products are for research use only. Not for human use.
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