Incensole Acetate


Catalog No. Size PriceQuantity
M12663-2 2mg solid $175
M12663-10 10mg solid $565

Description

Incensole acetate is a main constituent of Boswellia carterii resin, has neuroprotective effects against neuronal damage in traumatic and ischemic head injury. Incensole acetate reduces Aβ25–35-triggered apoptosis in hOBNSCs.

Product information

CAS Number: 34701-53-6

Molecular Weight: 348.52

Formula: C22H36O3

Chemical Name: (1R, 2S, 12S)-1, 5, 9-trimethyl-12-(propan-2-yl)-15-oxabicyclo[10.2.1]pentadeca-5, 9-dien-2-yl acetate

Smiles: C[C@@]12CC[C@@](CC=C(C)CCC=C(C)CC[C@@H]1OC(C)=O)(O2)C(C)C |c:6,11|

InChiKey: HVBACKJYWZTKCA-FZMWDMPZSA-N

InChi: InChI=1S/C22H36O3/c1-16(2)22-13-12-18(4)9-7-8-17(3)10-11-20(24-19(5)23)21(6,25-22)14-15-22/h8,12,16,20H,7,9-11,13-15H2,1-6H3/b17-8-,18-12-/t20-,21+,22+/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Incensole acetate (100 μM; pre-treatment 4 hours) significantly ameliorates Aβ 25–35-induced cell death, a 48–52% decrease in cell viability at Aβ25–35 is restored to 85–89% upon pre-treatment with IA. Incensole acetate (5-100 μM) pretreatment reverses increase in the mRNA and protein level of Bax, caspase 8, cyto c and decrease in the mRNA and protein level of Bcl2 induced by Aβ 25–35 in hOBNSCs.

References:

  1. El-Magd MA, et al. Incensole acetate prevents beta-amyloid-induced neurotoxicity in human olfactory bulb neural stem cells. Biomed Pharmacother. 2018 Sep;105:813-823.

Products are for research use only. Not for human use.

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