Isosilybin A


Catalog No. Size PriceQuantity
M12681-2 2mg solid $930
M12681-10 10mg solid $3,720

Description

Isosilybin A, a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity. Isosilybin A inhibits proliferation and induces G1 phase arrest and apoptosis in cancer cells, which activates apoptotic machinery in PCA cells via targeting Akt-NF-κB-androgen receptor (AR) axis.

Product information

CAS Number: 142796-21-2

Molecular Weight: 482.44

Formula: C25H22O10

Chemical Name: (2R, 3R)-3, 5, 7-trihydroxy-2-[(2R, 3R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2, 3-dihydro-1, 4-benzodioxin-6-yl]-3, 4-dihydro-2H-1-benzopyran-4-one

Smiles: COC1=CC(=CC=C1O)[C@H]1OC2=CC=C(C=C2O[C@@H]1CO)[C@H]1OC2=CC(O)=CC(O)=C2C(=O)[C@@H]1O

InChiKey: FDQAOULAVFHKBX-HKTJVKLFSA-N

InChi: InChI=1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-18-7-12(3-5-16(18)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3/t20-,23+,24-,25-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (207.28 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28(7):1533-42.
  2. Deep G, et al. Isosilybin A induces apoptosis in human prostate cancer cells via targeting Akt, NF-κB, and androgen receptor signaling. Mol Carcinog. 2010 Oct;49(10):902-12.

Products are for research use only. Not for human use.

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