Catalog No. Size PriceQuantity
M12711-2 2mg solid $145
M12711-10 10mg solid $435


EP1013 (F1013) is a broad-spectrum caspase selective inhibitor, used in the research of type 1 diabetes.

Product information

CAS Number: 223568-55-6

Molecular Weight: 382.38

Formula: C18H23FN2O6



Chemical Name: (3S)-3-[(2S)-2-{[(benzyloxy)carbonyl]amino}-3-methylbutanamido]-5-fluoro-4-oxopentanoic acid

Smiles: CC(C)[C@H](NC(=O)OCC1C=CC=CC=1)C(=O)N[C@@H](CC(O)=O)C(=O)CF


InChi: InChI=1S/C18H23FN2O6/c1-11(2)16(17(25)20-13(8-15(23)24)14(22)9-19)21-18(26)27-10-12-6-4-3-5-7-12/h3-7,11,13,16H,8-10H2,1-2H3,(H,20,25)(H,21,26)(H,23,24)/t13-,16-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (261.52 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vivo:

EP1013 (1, 3, 10 mg/kg) significantly improves marginal islet mass function. Two animals in the 10 mg/kg EP1013 treatment group exhibit primary islet graft nonfunction, but the diabetes reversal rate for this group is not significantly different from the 3 mg/kg EP1013, 1 mg/kg EP1013, or 10 mg/kg zVAD groups. EP1013 therapy enhances functional syngeneic islet mass and promotes longevity of islet graft function.


  1. Emamaullee JA, et al. The caspase selective inhibitor EP1013 augments human islet graft function and longevity in marginal mass islet transplantation in mice. Diabetes. 2008 Jun;57(6):1556-66.

Products are for research use only. Not for human use.

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