Dehydrotrametenolic acid


Catalog No. Size PriceQuantity
M12718-2 2mg solid $1,300
M12718-10 10mg solid $5,200

Description

Dehydrotrametenolic acid is a sterol isolated from the sclerotium of Poria cocos. Dehydrotrametenolic acid induces apoptosis through caspase-3 pathway. Dehydrotrametenolic acid has anti-tumor activity, anti-inflammatory, anti-diabetic effects.

Product information

CAS Number: 6879-05-6

Molecular Weight: 468.71

Formula: C31H48O3

Chemical Name: (2R)-2-[(1R, 3aR, 5aR, 7S, 9aS, 11aR)-7-hydroxy-3a, 6, 6, 9a, 11a-pentamethyl-1H, 2H, 3H, 3aH, 5H, 5aH, 6H, 7H, 8H, 9H, 9aH, 11H, 11aH-cyclopenta[a]phenanthren-1-yl]-6-methyl-5-methylideneheptanoic acid

Smiles: CC1(C)[C@@H]2CC=C3C(=CC[C@]4(C)[C@H](CC[C@]43C)[C@@H](CCC(=C)C(C)C)C(O)=O)[C@@]2(C)CC[C@@H]1O

InChiKey: ONFPYGOMAADWAT-OXUZYLMNSA-N

InChi: InChI=1S/C31H48O3/c1-19(2)20(3)9-10-21(27(33)34)22-13-17-31(8)24-11-12-25-28(4,5)26(32)15-16-29(25,6)23(24)14-18-30(22,31)7/h11,14,19,21-22,25-26,32H,3,9-10,12-13,15-18H2,1-2,4-8H3,(H,33,34)/t21-,22-,25+,26+,29-,30-,31+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: Soluble in DMSO

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Dehydrotrametenolic acid selectively inhibits the growth of H-ras transformed cells with a GI50 value of 40 μM[1].

References:

  1. Kang HM, et al. Dehydrotrametenolic acid selectively inhibits the growth of H-ras transformed rat2 cells and induces apoptosis through caspase-3 pathway. Life Sci. 2006 Jan 2;78(6):607-13.

Products are for research use only. Not for human use.

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