Dehydrotrametenolic acid is a sterol isolated from the sclerotium of Poria cocos. Dehydrotrametenolic acid induces apoptosis through caspase-3 pathway. Dehydrotrametenolic acid has anti-tumor activity, anti-inflammatory, anti-diabetic effects.
CAS Number: 6879-05-6
Molecular Weight: 468.71
Chemical Name: (2R)-2-[(1R, 3aR, 5aR, 7S, 9aS, 11aR)-7-hydroxy-3a, 6, 6, 9a, 11a-pentamethyl-1H, 2H, 3H, 3aH, 5H, 5aH, 6H, 7H, 8H, 9H, 9aH, 11H, 11aH-cyclopenta[a]phenanthren-1-yl]-6-methyl-5-methylideneheptanoic acid
Appearance: Solid Power
Purity: ≥98% (or refer to the Certificate of Analysis)
Solubility: Soluble in DMSO
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life: ≥360 days if stored properly.
Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.
Drug Formulation: To be determined
HS Tariff Code: 382200
How to use
Dehydrotrametenolic acid selectively inhibits the growth of H-ras transformed cells with a GI50 value of 40 μM.
- Kang HM, et al. Dehydrotrametenolic acid selectively inhibits the growth of H-ras transformed rat2 cells and induces apoptosis through caspase-3 pathway. Life Sci. 2006 Jan 2;78(6):607-13.
Products are for research use only. Not for human use.
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