Catalog No. Size PriceQuantity
M12755-2 2mg solid $130
M12755-10 10mg solid $390


MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment.

Product information

CAS Number: 1005264-47-0

Molecular Weight: 474.57

Formula: C27H26N2O4S

Chemical Name: 4-{8-[(3, 4-dimethylphenyl)sulfamoyl]-3H, 3aH, 4H, 5H, 9bH-cyclopenta[c]quinolin-4-yl}benzoic acid

Smiles: CC1=CC=C(C=C1C)NS(=O)(=O)C1=CC2C3C=CCC3C(NC=2C=C1)C1C=CC(=CC=1)C(O)=O


InChi: InChI=1S/C27H26N2O4S/c1-16-6-11-20(14-17(16)2)29-34(32,33)21-12-13-25-24(15-21)22-4-3-5-23(22)26(28-25)18-7-9-19(10-8-18)27(30)31/h3-4,6-15,22-23,26,28-29H,5H2,1-2H3,(H,30,31)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (210.72 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models. MX69-induced MDM2 downregulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro.

In Vivo:

MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation in vivo.


  1. Gu L, et al. Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. Cancer Cell. 2016 Oct 10;30(4):623-636

Products are for research use only. Not for human use.

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