MX69

MX69 is an inhibitor of MDM2/XIAP, used for cancer treatment.

Product information

CAS Number: 1005264-47-0

Molecular Weight: 474.57

Formula: C27H26N2O4S

Chemical Name: 4-{8-[(3, 4-dimethylphenyl)sulfamoyl]-3H, 3aH, 4H, 5H, 9bH-cyclopenta[c]quinolin-4-yl}benzoic acid

Smiles: CC1=CC=C(C=C1C)NS(=O)(=O)C1=CC2C3C=CCC3C(NC=2C=C1)C1C=CC(=CC=1)C(O)=O

InChiKey: XCBONKHCCRJMNW-UHFFFAOYSA-N

InChi: InChI=1S/C27H26N2O4S/c1-16-6-11-20(14-17(16)2)29-34(32,33)21-12-13-25-24(15-21)22-4-3-5-23(22)26(28-25)18-7-9-19(10-8-18)27(30)31/h3-4,6-15,22-23,26,28-29H,5H2,1-2H3,(H,30,31)

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 100 mg/mL (210.72 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

MX69 blocks the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation. MX69 shows minimal inhibitory effect on normal human hematopoiesis in vitro and is very well tolerated in animal models. MX69-induced MDM2 downregulation results not only in inhibition of XIAP expression, but also in activation of p53, which contributes to cancer cell apoptosis in vitro.

In Vivo:

MX69-induced MDM2 downregulation results in activation of p53 which contributes to inhibition of cancer cell proliferation in vivo.

References:

1. Gu L, et al. Discovery of Dual Inhibitors of MDM2 and XIAP for Cancer Treatment. Cancer Cell. 2016 Oct 10;30(4):623-636

Products are for research use only. Not for human use.