Deferiprone


Catalog No. Size PriceQuantity
M12771-2 2mg solid $80
M12771-10 10mg solid $240

Description

Deferiprone is the only orally active iron-chelating drug to be used therapeutically in conditions of transfusional iron overload. Target: Deferiprone is an orphan drug designed and developed primarily by academic initiatives for the treatment of iron overload in thalassaemia. Deferiprone has been used in several other iron or other metal imbalance conditions and has prospects of wider clinical applications. Deferiprone has high affinity for iron and interacts with almost all the iron pools at the molecular, cellular, tissue and organ levels. Doses of 50-120 mg/kg/day appear to be effective in bringing patients to negative iron balance. Deferiprone increases urinary iron excretion, which mainly depends on the iron load of patients and the dose of the drug.

Product information

CAS Number: 30652-11-0

Molecular Weight: 139.15

Formula: C7H9NO2

Chemical Name: 3-hydroxy-1, 2-dimethyl-1, 4-dihydropyridin-4-one

Smiles: CC1=C(O)C(=O)C=CN1C

InChiKey: TZXKOCQBRNJULO-UHFFFAOYSA-N

InChi: InChI=1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : 8.33 mg/mL (59.86 mM; Need ultrasonic) DMSO : 7.14 mg/mL (51.31 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

  1. Kontoghiorghes GJ, et al. Benefits and risks of deferiprone in iron overload in Thalassaemia and other conditions: comparison of epidemiological and therapeutic aspects with deferoxamine. Drug Saf. 2003;26(8):553-584.

Products are for research use only. Not for human use.

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